cytosolic innate immune sensing and signaling upon infection
Clicks: 254
ID: 233174
2016
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Abstract
Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here we highlight recent discoveries identifying the key mediators of nucleic acid and cyclic nucleotide sensing and discuss their importance in host defense. This review will also cover strategies evolved by pathogens to manipulate these pathways.
| Reference Key |
eradoshevich2016frontierscytosolic
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|---|---|
| Authors | ;Lilliana eRadoshevich;Olivier eDussurget |
| Journal | journal of magnetic resonance (san diego, calif : 1997) |
| Year | 2016 |
| DOI |
10.3389/fmicb.2016.00313
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| URL | |
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