hepatoprotective and antioxidative activities of cornus officinalis against acetaminophen-induced hepatotoxicity in mice
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2012
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Abstract
The fruit of Cornus officinalis Sieb. et Zucc. is commonly prescribed in Asian countries as a tonic formula. In this study, the hepatoprotective effect of ethanolic extracts of the fruit of C. officinalis (ECO) was investigated in a mouse model of acetaminophen- (APAP-) induced liver injury. Pretreatment of mice with ECO (100, 250, and 500 mg/kg for 7 days) significantly prevented the APAP (200 mg/kg) induced hepatic damage as indicated by the serum marker enzymes (AST, ALT, and LDH). Parallel to these changes, ECO treatment also prevented APAP-induced oxidative stress in the mice liver by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzymes (SOD, CAT, and HO-1) and glutathione. Liver injury and collagen accumulation were assessed using histological studies by hematoxylin and eosin staining. Our results indicate that ECO can prevent hepatic injuries associated with APAP-induced hepatotoxicity by preventing or alleviating oxidative stress.
| Reference Key |
lee2012evidence-basedhepatoprotective
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|---|---|
| Authors | ;Nam-Hun Lee;Chang-Seob Seo;Ho-young Lee;Da-Young Jung;Jun-Kyung Lee;Jin-Ah Lee;Kye Yong Song;Hyeun-kyoo Shin;Mee-Young Lee;Young Bae Seo;Hokyoung Kim;Hyekyung Ha |
| Journal | ACS applied materials & interfaces |
| Year | 2012 |
| DOI |
10.1155/2012/804924
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