studies on the two thymine residues in the catalytic core of 10-23 dnazyme: the impact on the catalysis of their 5-substituted functional groups

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ID: 232759
2017
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Abstract
In the 15-mer catalytic core of 10-23 DNAzyme, each residue contributes to the catalytic conformation differently. Here, the critically conserved T4 and the least conserved T8 were modified on their 5-position with hydroxyl, imidazolyl, and amino groups with a hydrogen-bonding ability. These external functional groups induced new interactions within the catalytic core, resulting in both negative and positive effects on the catalytic activity of 10-23 DNAzyme, and the different linkages could be used to modulate the effect of the functional groups. The conservation of T4 and T8 could be recognized at the level of the nucleobase, but at the level of the functional group, T4 is not completely conserved. Their 5-methyl groups could be modified for a better performance in terms of the DNAzyme.
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li2017moleculesstudies Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Pengyu Li;Shanshan Du;Yang Li;Junlin He
Journal Journal of ethnopharmacology
Year 2017
DOI
10.3390/molecules22071011
URL
http://www.mdpi.com/1420-3049/22/7/1011
Keywords
functional group chemical modifications

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