stereoselective reduction of imines with trichlorosilane using solid-supported chiral picolinamides
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ID: 232033
2016
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Abstract
The stereoselective reduction of imines with trichlorosilane catalyzed by chiral Lewis bases is a well-established procedure for the synthesis of enantio-enriched amines. Five supported cinchona-based picolinamides have been prepared and their activity tested in a model reaction. The comparison of different supporting materials revealed that polystyrene gave better results than silica in terms of stereoselectivity. The applicability of the solid-supported catalyst of choice to the reduction of different imines was also demonstrated. Additionally, for the first time, a catalytic reactor containing a polymer-immobilized chiral picolinamide has been employed for the stereoselective reduction of imines with trichlorosilane under continuous flow conditions.
| Reference Key |
fernandes2016moleculesstereoselective
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|---|---|
| Authors | ;Sílvia D. Fernandes;Riccardo Porta;Pedro C. Barrulas;Alessandra Puglisi;Anthony J. Burke;Maurizio Benaglia |
| Journal | Journal of ethnopharmacology |
| Year | 2016 |
| DOI |
10.3390/molecules21091182
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| URL | |
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