electroacupuncture restores locomotor functions after mouse spinal cord injury in correlation with reduction of pten and p53 expression

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ID: 232006
2018
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Ranked #49 of 189 articles by views in international journal of nanomedicine

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Abstract
Background: We previously showed that electroacupuncture (EA) at Jiaji points promotes expression of adhesion molecule L1 in spinal cord tissue after mouse spinal cord injury (SCI) and contributes to recovery of neural functions.Objective: We investigated the effects of EA on downstream signaling molecules of L1 and molecules relevant to apoptosis with the aim to understand the underlying molecular mechanisms.Methods: Female C57BL/6 mice were divided into a sham group, injury group, injury+acupuncture (AP) group and injury+EA group. We investigated the changes in cognate L1-triggered signaling molecules after SCI by immunofluorescence staining and immunoblot analysis.Results: Protein levels of phosphatase and tensin homolog (PTEN) and p53 were decreased by EA at different time points after injury, whereas the levels of phosphorylated mammalian target of rapamycin (pmTOR), p-Akt and phosphorylated extracellular signal-regulatedkinase (p-Erk) were increased. Also, levels of myelin basic protein (MBP) were increased by EA. AP alone showed less pronounced changes in expression of the investigated molecules, when compared to EA.Conclusion: We propose that EA contributes to neuroprotection by inhibiting PTEN and p53 expression and by increasing the levels of pmTOR/Akt/Erk and of MBP after SCI. These observations allow novel insights into the beneficial effects of EA via L1-triggered signaling molecules after injury.
Reference Key
wei2018frontierselectroacupuncture Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Zhe Wei;Zhe Wei;Weijiang Zhao;Melitta Schachner;Melitta Schachner
Journal international journal of nanomedicine
Year 2018
DOI
10.3389/fnmol.2018.00411
URL
https://www.frontiersin.org/article/10.3389/fnmol.2018.00411/full
Keywords
p53 spinal cord injury mtor pten electroacupuncture neuropsychiatry biological psychiatry

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