antioxidant and hypoglycemic activities of leaf extracts of three popular terminalia species

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2012
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Abstract
This study aimed to ascertain the antioxidant and hypoglycemic activity of methanolic extracts of the leaves of Terminalia arjuna, T. bellerica, and T. chebula. Extracts were evaluated for total phenolic, flavonoid, and tannin content, and in vitro antioxidant potential with DPPH, ORAC, and FRAP assays. The extracts' hypoglycemic activities were evaluated by hypoglycemic screening and an oral glucose tolerance test (OGTT) in normal rats. The methanolic extracts of T. chebula leaves exhibited the highest quantity of total phenolic and flavonoid content, followed by those of T. bellerica and T. arjuna. T. arjuna contained more tannin than T. bellerica did, but less than that of T. chebula. The scavenging capacity of T. chebula for the antioxidant DPPH was the highest of the extracts tested, as it recorded the lowest IC50 value of all 3 extracts. Likewise, the results attributed the T. chebula extract with the highest oxygen radical absorption capacity (ORAC). In the FRAP assay, the extracts' ferric reducing antioxidant abilities were T. arjuna > T. chebula > T. bellerica. This correlates the potential of polyphenolic content enriched with antioxidant capabilities and substantiates the results of the hypoglycemic screening and OGTT, which determined that the T. chebula extract had a better hypoglycemic effect in normal and glucose-induced hyperglycemic rats (p <0.001) than that of T. bellerica and T. arjuna, respectively. The use of these Terminalia species as food supplements may help in reducing oxidative stress and related diabetic complications. The phytoconstituents responsible for the hypoglycemic activity need to be isolated to elucidate the relationship between the extracts' antioxidant capacity and their hypoglycemic effects.
Reference Key
arya2012e-journalantioxidant Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Aditya Arya;Shaik Nyamathulla;Mohamed Ibrahim Noordin;Mustafa Ali Mohd
Journal Journal of pharmaceutical and biomedical analysis
Year 2012
DOI
10.1155/2012/859831
URL
http://dx.doi.org/10.1155/2012/859831
Keywords
chemistry

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