production of metallo-β-lactamase among pseudomonas aeruginosa strains isolated in the state of sergipe, brazil
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ID: 231696
2015
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Abstract
INTRODUCTION: Acquired production of metallo-β-lactamases is an important mechanism of resistance in Pseudomonas aeruginosa. The objective of this study was to investigate the production of metallo-β-lactamase and the genetic diversity among ceftazidime-resistant P. aeruginosa isolates from State of Sergipe, Brazil. METHODS: Metallo-β-lactamase was investigated using the disk approximation test and polymerase chain reaction (PCR). Genetic diversity was evaluated by pulsed-field gel electrophoresis (PFGE). RESULTS: A total of 48 (51.6%) isolates were resistant to ceftazidime. Six (12.2%) of these were positive for metallo-β-lactamase production. Only two (4.1%) of the ceftazidime-resistant isolates carried the bla SPM-1 gene. CONCLUSIONS: Production of metallo-β-lactamases was not the main mechanism of resistance to ceftazidime and carbapenems among P. aeruginosa strains in Sergipe, Brazil.
| Reference Key |
costa2015revistaproduction
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| Authors | ;Lívia Maria do Amorim Costa;Maria Emília de Castro Kling Fleming;Geraldo Renato de Paula;Lenise Arneiro Teixeira;Pedro Juan José Mondino;Sílvia Susana Bona de Mondino;Cláudia Rezende de Vieira Mendonça-Souza |
| Journal | mobile information systems |
| Year | 2015 |
| DOI |
10.1590/0037-8682-0198-2014
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