three atypical lethal cases associated with acute zika virus infection in suriname

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ID: 231185
2016
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Abstract
Acute Zika virus infection usually presents with a self-limiting triad of fever, rash and arthritis. There is limited information on severe or lethal cases. We report three cases of lethal acute Zika infection, confirmed with polymerase chain reaction, in adult patients with some co-morbidities. The patients showed rapid clinical deterioration with hemorrhagic and septic shock, and exaggerated acute and innate inflammatory responses with pronounced coagulopathy, and died soon after admission to the hospital. It remains unclear whether the fatal outcomes were due to acute Zika virus infection alone or to the combination with exacerbated underlying prior disease or co-infection. Nonetheless, the severity of these cases implies that increased awareness for atypical presentations of Zika virus infection, and careful clinical assessment of patients with symptoms of Zika, is warranted during current and future outbreaks.
Reference Key
zonneveld2016idcasesthree Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rens Zonneveld;Jimmy Roosblad;Jan Willem van Staveren;Jan C. Wilschut;Stephen G.S. Vreden;John Codrington
Journal optics letters
Year 2016
DOI
10.1016/j.idcr.2016.07.009
URL
http://www.sciencedirect.com/science/article/pii/S2214250916300610
Keywords
zika zikv sepsis hemorrhagic feverinfectious and parasitic diseases

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