resolvin d1 reduces the immunoinflammatory response of the rat eye following uveitis
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ID: 230858
2012
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Abstract
This study investigated whether the administration of resolvin D1 to rats with endotoxininduced uveitis (EIU) ameliorates the immuno-inflammatory profile of the eye. 24 h after the administration of 200 μg LPS into the footpad of Sprague-Dawley rats, severe changes of the structure of the eye occurred concomitantly with a severe inflammatory and immune response. These latter included strong infiltration of PMN leukocytes CD11b+ T-lymphocytes CD4+ and CD8+ within the eye and a significant release of the cytokines/chemokines TNF-alpha, CXCL8, and RANTES too. Bolus of resolvin D1 (RvD1; 10–100–1000 ng/kg in 200 μL of sterile saline via the tail vein) significantly and dose-dependently (i) reduced the development of the ocular derangement caused by LPS; (ii) reduced the clinical score attributed to EIU; (iii) reduced the protein concentration and myeloperoxidase activity (MPO) in aqueous humor (AqH); and (iv) reduced neutrophils, T-lymphocytes, and cytokines within the eye.
| Reference Key |
settimio2012mediatorsresolvin
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|---|---|
| Authors | ;Rossi Settimio;Di Filippo Clara;Ferraraccio Franca;Simonelli Francesca;D'Amico Michele |
| Journal | polyhedron |
| Year | 2012 |
| DOI |
10.1155/2012/318621
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| URL | |
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