protective role of genistein in acute liver damage induced by carbon tetrachloride
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2007
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Abstract
Aim. In the present study, we investigated the protective
effect of genistein in experimental acute liver damage induced by
CCl4.
Method. Forty rats were equally allocated to 5 groups. The
first group was designated as the control group (group 1). The second group
was injected with intraperitoneal CCl4 for 3 days (group 2). The third group was injected
with subcutaneous 1 mg/kg genistein for 4 days starting one
day before CCl4 injection. The fourth group was injected with
intraperitoneal CCl4 for 7 days. The fifth group was injected with
subcutaneous 1 mg/kg genistein for 8 days starting one day before
CCl4 injection. Plasma and liver tissue
malondialdehyde (MDA) and liver glutathione levels, as well as AST
and ALT levels were studied. A histopathological examination was conducted.
Results. Liver tissue MDA levels were found significantly
lower in group 3, in comparison to group 2 (P<.05). Liver tissue MDA level in group 5 was significantly lower
than that in group 4
(P<.001).
Liver tissue glutathione levels were higher in group 5 and 3, relative
to groups 4 and 2, respectively
(P>.05 for each). Inflammation and focal necrosis decreased in
group 3, in comparison to group 2 (P<.001 for each). Inflammation and focal necrosis in group
5 was lower than that in group 4
(P<.001). Actin expression decreased significantly in group 5, relative to group 4
(P<.05).
Conclusion. Genistein has anti-inflammatory and antinecrotic
effects on experimental liver damage caused by CCl4. Genistein reduces liver damage by
preventing lipid peroxidation and strengthening antioxidant systems.
| Reference Key |
kuzu2007mediatorsprotective
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|---|---|
| Authors | ;Nalan Kuzu;Kerem Metin;Adile Ferda Dagli;Fatih Akdemir;Cemal Orhan;Mehmet Yalniz;Ibrahim Hanifi Ozercan;Kazim Sahin;Ibrahim Halil Bahcecioglu |
| Journal | polyhedron |
| Year | 2007 |
| DOI |
10.1155/2007/36381
|
| URL | |
| Keywords |
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