effects of platycodin d on reflux esophagitis due to modulation of antioxidant defense systems

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ID: 230609
2018
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Abstract
Aims. The effects of platycodin D (PD) pretreatment were examined in reflux esophagitis (RE) induced rats. Methods. Sham, control, and omeprazole (OMP) group were pretreated with distilled water or OMP as a reference, respectively, and PD pretreated groups were given 3 different PD doses once a day for 7 days. One hour after last pretreatment, RE was induced by ligation of the forestomach and pylorus. At 8 h after operation, all animals were sacrificed. Results. PD showed significant dose-dependent reduction of gastric secretion, myeloperoxidase activity, and RE lesion areas of esophagus and stomach mucosa. There was a reduction of lipid peroxidation in 2 doses of PD groups and elevation of antioxidant enzyme activity in all PD groups. Gastric hexose and sialic acid were significantly increased in PD groups, while collagen was reduced. Plasma histamine levels were significantly reduced in all PD groups, but not in the OMP group. Total invasive lesion sizes of esophagus and gastric fundus were significantly decreased in all PD groups. Thicknesses in esophagus of all PD groups were significantly decreased and thicknesses of funds were significantly increased except lowest PD dose. Conclusions. Therapeutic effects of PD on the esophageal and gastric lesions were shown in RE induced rats dose-dependently. The PD pretreatment had significant antioxidant effects with regulation of histamine levels. This study provides useful information regarding the effectiveness of the drug for RE and further novel drug discovery using natural herbal products.
Reference Key
cho2018evidence-basedeffects Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Su-Yeon Cho;Chang-Hyun Song;Ji-Eun Lee;Seong Hun Choi;Sae-Kwang Ku;Soo-Jin Park
Journal ACS applied materials & interfaces
Year 2018
DOI
10.1155/2018/7918034
URL
http://dx.doi.org/10.1155/2018/7918034
Keywords
Other systems of medicine

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