lower choline-containing metabolites/creatine (cr) rise and failure to sustain naa/cr levels in the dorsolateral prefrontal cortex are associated with depressive episode recurrence under maintenance therapy: a proton magnetic resonance spectroscopy retrospective cohort study

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2017
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Abstract
BackgroundThe aim of this study was to evaluate the relationship between changes in proton magnetic resonance spectroscopy (1H-MRS) parameters at the start of the index episode recovery phase and at recurrence in patients with recurrent depression who were treated with prolonged maintenance therapy.Methods1H-MRS parameters were analyzed in 48 patients with recurrent depression who required maintenance therapy with antidepressant medication prescribed by a psychiatrist and who continued with the same antidepressant during the maintenance phase, either to recurrence of depression, completion of the 10-year observation period, or the start of the withdrawal phase (tapering-off antidepressant). N-acetylaspartate (NAA), choline-containing metabolites (Cho), creatine (Cr), and glutamine/glutamate were measured at the start of the recovery phase and 6 months later.ResultsRecurrent depressive episodes occurred in 20 patients. These individuals had a smaller increase in Cho/Cr after the beginning of the recovery phase compared to the non-recurrent patient group and also exhibited a decreased NAA/Cr ratio.ConclusionSustainable NAA and increased Cho levels at the onset of the recovery phase of the index episode are early markers of antidepressant effectiveness associated with a lower risk of major depressive disorder recurrence. The NAA and Cho changes in the non-recurrent group may be attributable to increased brain resilience, contrary to the transient temporal effect observed in subjects who experienced a depressive episode.
Reference Key
henigsberg2017frontierslower Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Neven Henigsberg;Helena Šarac;Marko Radoš;Marko Radoš;Milan Radoš;David Ozretić;David Ozretić;Tamara Foro;Viktorija Erdeljić Turk;Pero Hrabač;Maja Bajs Janović;Benedict Rak;Petra Kalember
Journal journal of experimental psychology general
Year 2017
DOI
10.3389/fpsyt.2017.00277
URL
http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00277/full
Keywords
depression antidepressants recurrence magnetic resonance spectroscopypsychiatry

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