individual aging and cancer risk: how are they related?

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ID: 229912
2003
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Abstract
When individuals get older, the risk of many chronic diseases increases. This increase is in agreement with common theories of aging, such as mutation accumulation, wear and tear, antagonistic pleiotropy, etc. Surprisingly, however, the risk of some chronic conditions (e.g. asthma, arterial hypertension) declines in the old. The cancer incidence rate also declines at old ages after a steep increase during adult life. It contrasts with the continuing increase in total mortality that is often referred to as the aging process. Which forces contribute to a decline in cancer risk in the old? In this paper we review evidence from experimental biology, illustrating the ambivalent role of individual aging in cancer risk, in particular in forming non-monotonic age-patterns of cancer incidence rate. We show that age-associated changes in the organism may contribute not only to the rise, but also to the deceleration and the decline in cancer risk at old ages.
Reference Key
noauthor2003demographicindividual Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
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Journal journal of urban planning and development
Year 2003
DOI
DOI not found
URL
http://www.demographic-research.org/volumes/vol9/8/
Keywords
population vital events

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