a novel method for quantitative determination of aceclofenac in bulk drug and tablets using sodium salicylate as a hydrotropic solubilizing agent

Clicks: 225
ID: 229807
2010
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #22 of 30 articles by views in solid state communications

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
In titrimetric analysis costlier organic solvents are more often employed tosolubilize the poorly water-soluble drugs. Volatility and pollution are drawbacks of suchsolvents. Various techniques are employed to enhance the aqueous solubility of poorlywater-soluble drugs. Hydrotropic solubilization phenomenon has been widely used toenhance the aqueous solubility of large number of poorly water-soluble drugs. Aqueoussolubility of aceclofenac bulk drug [a poorly water-soluble NSAID] was enhanced to agreat extent i.e., 400 folds with 2.5 M sodium salicylate. The primary objective of thepresent investigation was to employ this hydrotropic solution to extract the drug from itsdosage forms, precluding the use of costlier organic solvents. The proposed method ofanalysis is new, simple, accurate, environmentally friendly and reproducible. Statisticaldata proved the accuracy, reproducibility and the precision of the proposed method. Theresults of titrimetric analysis by use of hydrotropy compared very well with the results ofPharmacopoeial method.
Reference Key
moondra2010journala Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Shruti Moondra;R. K. Maheshwari
Journal solid state communications
Year 2010
DOI
DOI not found
URL
http://122.168.195.169/Online%20Admission/CourseInstr.aspx?STS=4&MID=53&Title=A%20Novel%20Method%20for%20Quantitative%20Determination%20of%20%20%20%20Aceclofenac%20in%20Bulk%20Drug%20and%20Ta
Keywords
solubilization pharmacologypharmacy and materia medica titrimetrytherapeutics

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.