simple and efficient synthesis of racemic 2-(tert-butoxycarbon-ylamino)-2-methyl-3-(1h-1,2,4-triazol-1-yl)propanoic acid, a new derivative of β-(1,2,4-triazol-1-yl)alanine
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ID: 229749
2011
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Abstract
A simple synthetic approach to racemic N-tert-butyloxycarbonyl-2-methyl-3-(1H-1,2,4-triazol-1-yl)alanine (5) in four steps and 68% overall yield starting from oxazoline derivative 1 is reported. This synthesis involves the alkylation of 1H-1,2,4-triazole with an O-tosyloxazoline derivative, followed by an oxazoline ring-opening reaction and oxidation of the N-protected β‑aminoalcohol by potassium permanganate.
| Reference Key |
kerbal2011moleculessimple
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|---|---|
| Authors | ;Abdelali Kerbal;Abdelrhani Elachqar;Anouar Alami;Abdelilah El-Hallaoui;Younas Aouine;Hassane Faraj |
| Journal | Journal of ethnopharmacology |
| Year | 2011 |
| DOI |
10.3390/molecules16043380
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| URL | |
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