in silico structural and functional prediction of african swine fever virus protein-b263r reveals features of a tata-binding protein

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ID: 229669
2018
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Abstract
African swine fever virus (ASFV) is the etiological agent of ASF, a fatal hemorrhagic fever that affects domestic pigs. There is currently no vaccine against ASFV, making it a significant threat to the pork industry. The ASFV genome sequence has been published; however, about half of ASFV open reading frames have not been characterized in terms of their structure and function despite being essential for our understanding of ASFV pathogenicity. The present study reports the three-dimensional structure and function of uncharacterized protein, pB263R (NP_042780.1), an open reading frame found in all ASFV strains. Sequence-based profiling and hidden Markov model search methods were used to identify remote pB263R homologs. Iterative Threading ASSEmbly Refinement (I-TASSER) was used to model the three-dimensional structure of pB263R. The posterior probability of fold family assignment was calculated using TM-fold, and biological function was assigned using TM-site, RaptorXBinding, Gene Ontology, and TM-align. Our results suggests that pB263R has the features of a TATA-binding protein and is thus likely to be involved in viral gene transcription.
Reference Key
kinyanyi2018peerjin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Dickson Kinyanyi;George Obiero;George F.O. Obiero;Peris Amwayi;Stephen Mwaniki;Mark Wamalwa
Journal pediatrics
Year 2018
DOI
10.7717/peerj.4396
URL
https://peerj.com/articles/4396/
Keywords
african swine fever virus sequence homology searchmedicine

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