morphological, immunocytochemical, and biochemical studies of rat costal chondrocytes exposed to il-1β and tgf-β1
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ID: 229529
2017
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Abstract
This study was undertaken to determine the effects of IL-1β and TGF-β1 on the expression of differentiation-associated genes in chondrocytes in vitro. Rat costal chondrocytes were exposed to different concentrations of IL-1β and TGF-β1 for 48 h and tested for gene expression. IL-1β increased the expression of aggrecanase-1 and aggrecanase-2 and decreased the content of aggrecan and collagen II. Low concentration of TGF-β1 decreased the expression of aggrecan and collagen II and increased the expression of aggrecanase-2. However, the level of aggrecanase-1 was significantly elevated in the presence of high concentration of TGF-β1. IL-1β and TGF-β1 show the ability to modulate the production of aggrecan and collagen II in chondrocytes in vitro.
| Reference Key |
li2017journalmorphological,
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|---|---|
| Authors | ;Xiaoli Li;Xiaoyong Ren;Sisi Li;Jianmin Liang;Xiaoyan Zhao;Ting Wang;Zhenghui Wang |
| Journal | journal of political philosophy |
| Year | 2017 |
| DOI |
10.1155/2017/9747264
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| URL | |
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