a network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy
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ID: 229240
2014
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Abstract
Contrast-induced nephropathy is a common complication of iodinated contrast administration. Statins may reduce the risk of contrast-induced nephropathy, but data remain inconclusive. We summarized the evidence based on statins for the prevention of contrast-induced nephropathy with a network meta-analysis. Randomized trials focusing on statins were searched and pooled with random-effect odds ratios. A total of 14 trials (6,160 patients) were included, focusing on atorvastatin (high/low dose), rosuvastatin (high dose), simvastatin (high/low dose), and placebo or no statin therapy before contrast administration. The risk of contrast-induced nephropathy was reduced by atorvastatin high dose and rosuvastatin high dose, with no difference between these two agents. Results for atorvastatin low dose and simvastatin (high/low dose) in comparison to placebo were inconclusive. Atorvastatin and rosuvastatin administered at high doses and before iodinated contrast administration have a consistent and beneficial preventive effect on contrast-induced nephropathy and may actually halve its incidence.
| Reference Key |
peruzzi2014biomeda
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| Authors | ;Mariangela Peruzzi;Leonardo De Luca;Henrik S. Thomsen;Enrico Romagnoli;Fabrizio D’Ascenzo;Massimo Mancone;Gennaro Sardella;Luigi Lucisano;Antonio Abbate;Giacomo Frati;Giuseppe Biondi-Zoccai |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2014 |
| DOI |
10.1155/2014/213239
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| URL | |
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