erythritol availability in bovine, murine and human models highlights a potential role for the host aldose reductase during brucella infection

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2017
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Ranked #710 of 875 articles by views in journal of magnetic resonance (san diego, calif : 1997)

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Abstract
Erythritol is the preferential carbon source for most brucellae, a group of facultative intracellular bacteria that cause a worldwide zoonosis. Since this polyol is abundant in genital organs of ruminants and swine, it is widely accepted that erythritol accounts at least in part for the characteristic genital tropism of brucellae. Nevertheless, proof of erythritol availability and essentiality during Brucella intracellular multiplication has remained elusive. To investigate this relationship, we compared ΔeryH (erythritol-sensitive and thus predicted to be attenuated if erythritol is present), ΔeryA (erythritol-tolerant but showing reduced growth if erythritol is a crucial nutrient) and wild type B. abortus in various infection models. This reporting system indicated that erythritol was available but not required for B. abortus multiplication in bovine trophoblasts. However, mice and humans have been considered to lack erythritol, and we found that it was available but not required for B. abortus multiplication in human and murine trophoblastic and macrophage-like cells, and in mouse spleen and conceptus (fetus, placenta and envelopes). Using this animal model, we found that B. abortus infected cells and tissues contained aldose reductase, an enzyme that can account for the production of erythritol from pentose cycle precursors.
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Authors ;Thibault Barbier;Arnaud Machelart;Amaia Zúñiga-Ripa;Hubert Plovier;Charlotte Hougardy;Elodie Lobet;Kevin Willemart;Eric Muraille;Xavier De Bolle;Emile Van Schaftingen;Ignacio Moriyón;Jean-Jacques Letesson
Journal journal of magnetic resonance (san diego, calif : 1997)
Year 2017
DOI
10.3389/fmicb.2017.01088
URL
http://journal.frontiersin.org/article/10.3389/fmicb.2017.01088/full
Keywords
aldose reductase human trophoblastmicrobiology

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