age and ebola viral load correlate with mortality and survival time in 288 ebola virus disease patients

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ID: 228185
2016
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Abstract
Background: A Chinese medical team managed Ebola virus disease (EVD) patients in Sierra Leone from October 2014 to March 2015 and attended to 693 suspected patients, of whom 288 had confirmed disease. Methods: A retrospective study was conducted of the 288 patients with confirmed disease. Clinical symptoms, manifestations, and serum viral load were analyzed and compared among the different groups for mortality and survival time. Results: Among the 288 confirmed EVD patients (149 male and 139 female, median age 28 years, and median log viral load 6.68), 98 died, 36 recovered, and 154 were lost to follow-up. Common symptoms were fever (77.78%), fatigue (64.93%), abdominal pain (64.58%), headache (62.85%), and diarrhea (61.81%). Compared to patients aged < 18 years, those who were older than 40 years had a higher probability of death (odds ratio 2.855, p = 0.044). Patients with a viral load of >106 copies/ml had a higher case fatality rate than those with <106 copies/ml (odds ratio 3.095, p = 0.004). Cox regression showed that age, viral load, and the presence of diarrhea correlated with mortality. Conclusion: Patients with a high viral load, of older age, and with diarrhea had a higher mortality and shorter survival time.
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li2016internationalage Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jin Li;Hui-Juan Duan;Hao-Yang Chen;Ying-Jie Ji;Xin Zhang;Yi-Hui Rong;Zhe Xu;Li-Jian Sun;Ji-Yuan Zhang;Li-Ming Liu;Bo Jin;Jian Zhang;Ning Du;Hai-Bin Su;Guang-Ju Teng;Yue Yuan;En-Qiang Qin;Hong-Jun Jia;Shu Wang;Tong-Sheng Guo;Ye Wang;Jin-Song Mu;Tao Yan;Zhi-Wei Li;Zheng Dong;Wei-Min Nie;Tian-Jun Jiang;Chen Li;Xu-Dong Gao;Dong Ji;Ying-Jie Zhuang;Lei Li;Li-Fu Wang;Wen-Gang Li;Xue-Zhang Duan;Yin-Ying Lu;Zhi-Qiang Sun;Alex B.J. Kanu;Sheku M. Koroma;Min Zhao;Jun-Sheng Ji;Fu-Sheng Wang
Journal israel journal of chemistry
Year 2016
DOI
10.1016/j.ijid.2015.10.021
URL
http://www.sciencedirect.com/science/article/pii/S1201971215002556
Keywords
ebola virus disease treatment

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