changes in expression of the clock gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment
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2017
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Abstract
PurposeMetabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment.MethodsPeripheral blood was collected from male patients diagnosed with severe OSAS (apnea-hypopnea index ≥ 30/h) before and after treatment initiation. qPCR was used to measure mRNA levels of genes associated with the central circadian pacemaker including CLOCK, BMAL1, Cry1, Cry2, and three Period genes (Per 1, 2, 3) in peripheral blood mononuclear cells (PBMCs).ResultsWe found statistically significant differences for CLOCK (p-value = 0.022) expression in PBMCs of OSAS patients which were not reverted by treatment with CPAP. We have also found a substantial decrease in the slow wave sleep (SWS) content in OSAS patients (p-value < 0.001) that, contrary to REM sleep, was not corrected by CPAP (p-value = 0.875).ConclusionCPAP treatment does not correct substantial changes in expression of core clock genes in OSAS patients. Because CPAP treatment is also unable to normalize the SWS in these patients, it is likely that additional therapeutic interventions that increase SWS content and complement the benefits of CPAP are required to more effectively reduce the known increased cardiovascular risk associated with OSAS patients.
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moreira2017frontierschanges
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| Authors | ;Susana Moreira;Susana Moreira;Raquel Rodrigues;Raquel Rodrigues;André B. Barros;Nadja Pejanovic;Ana Neves-Costa;Dora Pedroso;Cláudia Pereira;Dina Fernandes;João Valença Rodrigues;Cristina Barbara;Luís Ferreira Moita |
| Journal | Stroke |
| Year | 2017 |
| DOI |
10.3389/fmed.2017.00187
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| URL | |
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