the effect of glutamate receptor agonists on mouse retinal astrocyte [ca2+]i
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2016
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Abstract
Calcium-imaging techniques were used to determine if mouse retinal astrocytes in situ respond to agonists of ionotropic (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, AMPA; N-methyl-D-aspartate, NMDA) and metabotropic (S-3,5-dihydroxyphenylglycine, DHPG; trans-1-amino-1,3-cyclopentanedicarboxylic acid, ACPD) glutamate receptors. In most cases we found no evidence that retinal astrocyte intracellular calcium ion concentration (Ca2+i) increased in response to these glutamate agonists. The one exception was AMPA that increased Ca2+i in some, but not all, mouse retinal astrocytes in situ. However, AMPA did not increase Ca2+i in mouse retinal astrocytes in vitro, suggesting that the effect of AMPA in situ may be indirect.
| Reference Key |
blandford2016biomedthe
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|---|---|
| Authors | ;Stephanie N. Blandford;William H. Baldridge |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2016 |
| DOI |
10.1155/2016/8178162
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