estudo das relações entre estrutura e atividade de parabenos: uma aula prática
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ID: 227306
2013
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Abstract
Parabens are p-hydroxybenzoic acid esters widely used as preservatives. With the aim of teaching the structure-activity relationships (SAR) knowledge in a practical form, this paper proposed a practical class to view the SAR of parabens as antimicrobial agents. Methyl, ethyl, n-propyl, isopropyl and isopentyl paraben compounds were synthesized and their respective antimicrobial activities were assessed through determination of minimum inhibitory concentrations (MIC) against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 stains. With the MIC values, it was possible to verify theircorrelation with calculated lipophilicity (ClogP). This method can be applied in practical Medicinal Chemistry classes.
| Reference Key |
fernandes2013qumicaestudo
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| Authors | ;João Paulo dos Santos Fernandes;Giovanna Savino;André Cortinas Gonçalves Amarante;Milena Rodrigues de Sousa;Geane Ramos da Silva;Maria Eliza Cianciulli;Michelle Fidelis Corrêa;Márcio Ferrarini |
| Journal | greece and rome |
| Year | 2013 |
| DOI |
10.1590/S0100-40422013000600026
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