a novel luminol-based chemiluminescence method for the determination of amikacin sulfate in serum by using trivalent copper-periodate complex

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ID: 227011
2013
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Ranked #120 of 187 articles by views in Frontiers in plant science

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Abstract
A novel chemiluminescence (CL) reaction was based on the oxidizing reaction of luminol by the trivalent copper-periodate complex (K5[Cu(HIO6)2], DPC) in alkaline medium. The CL intensity could be enhanced in the presence of amikacin sulfate (AKS). A new CL method was developed for the determination of AKS by coupling with flow injection (FI) technology. Because of the distinctive oxidative effect of DPC, the luminol-based CL reaction could occur at a low concentration of 10−7M. The relative CL intensity was proportional to the concentration of AKS in the range of 4.0×10−9–4.0×10−6g/mL with the detection limit of 1.2×10−9g/mL. The relative standard deviation was 2.1% for 8.0×10−9g/mL AKS (n=9). The proposed method was successfully applied to the direct determination of AKS at the level of ng/mL in serum samples. The recovery varied from 97.0% to 106.3%. A possible mechanism of the CL reaction was discussed in detail by relating to the CL kinetic characteristics and electrochemical activities of the oxidant DPC. Keywords: Amikacin sulfate, Chemiluminescence, K5[Cu(HIO6)2], Flow injection, Serum sample
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hu2013journala Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yu-Fei Hu, Gong-Ke Li, Zhu-Jun Zhang
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Journal Frontiers in plant science
Year 2013
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S209517791300004X
Keywords
therapeutics multi-agent system pharmacology jadetechnology

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