synthesis of ∆3-2-hydroxybakuchiol analogues and their growth inhibitory activity against rat umr106 cells
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ID: 226839
2014
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Abstract
A series of ∆3-2-hydroxybakuchiol analogues have been synthesized and tested for their growth inhibitory activity against rat UMR106 cells by using the MTT method. Some of them exhibit enhanced activities compared with the natural product, and the preliminary SAR profile shows that the chain tail on the natural product could be subtly modified to enhance the activity and the aromatic moiety or the terminal olefin on the main chain can also be modified without any evident loss of activity. The stereo-configuration of the quaternary chiral center has an important influence on the activity.
| Reference Key |
zhao2014moleculessynthesis
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|---|---|
| Authors | ;Qun Zhao;Qianqian Xu;Guangsheng Shan;Chao Dong;Hong Zhang;Xinsheng Lei |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI |
10.3390/molecules19022213
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| URL | |
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