identification and antibacterial evaluation of bioactive compounds from <em>garcinia kola</em> (heckel) seeds

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ID: 226785
2012
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Abstract
We assessed the bioactivity of <em>G. kola</em> seeds on <em>Streptococcus pyogenes</em>, <em>Staphylococcus aureus</em>, <em>Plesiomonas shigelloides</em> and<em> Salmonella typhimurium</em>. The crude ethyl acetate, ethanol, methanol, acetone and aqueous extracts were screened by the agar-well diffusion method and their activities were further determined by Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays. The extracts were fractionated by Thin Layer Chromatography (TLC). Bioautography was used to assess the activity of the possible classes of compounds present in the more active extracts. Column chromatography was used to purify the active compounds from the mixture, while GC-MS was used to identify the phytocomponents of the fractions. The inhibition zone diameters of the extracts ranged from 0–24 ± 1.1 mm, while MIC and MBC values ranged between 0.04–1.25 mg/mL and 0.081–2.5 mg/mL, respectively. The chloroform/ethyl acetate/formic acid (CEF) solvent system separated more active compounds. The MIC of the fractions ranged between 0.0006–2.5 mg/mL. CEF 3 (F3), CEF 11 (F11) and CEF 12 (F12) revealed the presence of high levels of linoleic acid, 1,2-benzenedicarboxylic acid and 2,3-dihydro-3,5-dihydroxy-6-methyl ester, respectively. The results obtained from this study justify the use of this plant in traditional medicine and provide leads which could be further exploited for the development of new and potent antimicrobials.
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seanego2012moleculesidentification Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Christinah T. Seanego;Roland N. Ndip
Journal Journal of ethnopharmacology
Year 2012
DOI
10.3390/molecules17066569
URL
http://www.mdpi.com/1420-3049/17/6/6569
Keywords
Antimicrobial activity Medicinal Plants minimum inhibitory concentration

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