changes in b-cell counts and percentages during primary hiv infection associated with disease progression in hiv-infected men who have sex with men: a preliminary study
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2015
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Abstract
Numerous anomalies in B-cell phenotypes and functions have been described in HIV-infected individuals. However, the actual relationship between B cells and disease progression remains unclear. In this study, we investigated B-cell counts/percentages during a 12-month infection period in HIV-infected individuals that eventually developed into typical progressors (TPs) or rapid progressors (RPs). We found, after 12 months of infection, the baseline B-cell counts/percentages correlated positively with CD4+ T-cell counts (P=0.0006 and P=0.026) and negatively with HIV viral set points (P=0.014 and P=0.002). Kaplan-Meier survival analysis showed that high baseline B-cell counts/percentages were associated with a slow CD4-cell decline. B-cell kinetics indicated the baseline B-cell counts/percentages could be factors distinguishing between TPs and RPs. The combination of the baseline B-cell counts and percentages was associated with rapid disease progression (a 80.7% predictive value as measured by the area under the curve). These results indicate that the baseline B-cell counts/percentages might be associated with HIV disease progression.
| Reference Key |
cui2015biomedchanges
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| Authors | ;Chen Cui;Yongjun Jiang;Zining Zhang;Qinghai Hu;Zhenxing Chu;Junjie Xu;Bin Zhao;Haibo Ding;Jing Liu;Xiaoxu Han;Yaming Cao;Hong Shang |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2015 |
| DOI |
10.1155/2015/468194
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| URL | |
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