genetic programming of hypertension

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ID: 226523
2018
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Abstract
The heritability of hypertension (HTN) is widely recognized and as a result, extensive studies ranging from genetic linkage analyses to genome-wide association studies are actively ongoing to elucidate the etiology of both monogenic and polygenic forms of HTN. Due to the complex nature of essential HTN, however, single genes affecting blood pressure (BP) variability remain difficult to isolate and identify and have rendered the development of single-gene targeted therapies challenging. The roles of other causative factors in modulating BP, such as gene–environment interactions and epigenetic factors, are increasingly being brought to the forefront. In this review, we discuss the various monogenic HTN syndromes and corresponding pathophysiologic mechanisms, the different methodologies employed in genetic studies of essential HTN, the mechanisms for epigenetic modulation of essential HTN, pharmacogenomics and HTN, and finally, recent advances in genetic studies of essential HTN in the pediatric population.
Reference Key
ahn2018frontiersgenetic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sun-Young Ahn;Sun-Young Ahn;Charu Gupta;Charu Gupta
Journal disease markers
Year 2018
DOI
10.3389/fped.2017.00285
URL
http://journal.frontiersin.org/article/10.3389/fped.2017.00285/full
Keywords
hypertension Children genetics epigenetics pharmacogenomics

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