regulation of cell proliferation and differentiation by pparβ/δ
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ID: 226419
2008
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Abstract
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a ligand-activated transcription factor with essential functions in the regulation of lipid catabolism, glucose homeostasis, and inflammation, which makes it a potentially relevant drug target for the treatment of major human diseases. In addition, there is strong evidence that PPARβ/δ modulates oncogenic signaling pathways and tumor growth. Consistent with these observations, numerous reports have clearly documented a role for PPARβ/δ in cell cycle control, differentiation, and apoptosis. However, the precise role of PPARβ/δ in tumorigenesis and cell proliferation remains controversial. This review summarizes our current knowledge and proposes a model corroborating the discrepant data in this area of research.
| Reference Key |
mller2008pparregulation
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|---|---|
| Authors | ;Rolf Müller;Markus Rieck;Sabine Müller-Brüsselbach |
| Journal | Life (Basel, Switzerland) |
| Year | 2008 |
| DOI |
10.1155/2008/614852
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| URL | |
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