role of pacap in female fertility and reproduction at gonadal level - recent advances

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ID: 226418
2012
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Abstract
Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide, first isolated from hypothalamic extracts, but later shown in peripheral organs, such as endocrine glands, gastrointestinal system, cardiovascular system and reproductive organs. PACAP plays a role in fertility and reproduction. Numerous studies report on the gonadal regulatory effects of PACAP at hypothalamo-hypophyseal levels. However, the local effects of PACAP at gonadal levels are also important. The present review summarizes the effects of PACAP in the ovary. PACAP and its receptors are present in the ovary, and PACAP plays a role in germ cell migration, meiotic division, follicular development and atresia. The autocrine-paracrine hormonal effects seem to play a regulatory role in ovulation, luteinization and follicular atrophy. Altogether, PACAP belongs to the ovarian regulatory peptides.
Reference Key
ereglodi2012frontiersrole Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Dora eReglodi;Andrea eTamas;Miklos eKoppan;Donat eSzogyi;Laura eWelke
Journal aip advances
Year 2012
DOI
10.3389/fendo.2012.00155
URL
http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00155/full
Keywords
ovary ovulation clinical endocrinology oocytediseases of the endocrine glands

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