role of nmda receptor glun2d subunit in the antidepressant effects of enantiomers of ketamine
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2017
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Abstract
We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted significant antidepressant effects on restraint stress-induced depression in both wildtype and GluN2D-KO mice. The antidepressant effects of (RS)-ketamine and (S)-ketamine were sustained 96 h after the injection in both wildtype and GluN2D-KO mice, but such sustained antidepressant effects of (R)-ketamine were only observed in wildtype mice. These data suggest that the GluN2D subunit is critical for the sustained antidepressant effects of (R)-ketamine.
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ide2017journalrole
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| Authors | ;Soichiro Ide;Yuiko Ikekubo;Masayoshi Mishina;Kenji Hashimoto;Kazutaka Ikeda |
| Journal | plant direct |
| Year | 2017 |
| DOI |
10.1016/j.jphs.2017.11.001
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