Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations.

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ID: 22507
2018
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Abstract
Associations between prenatal household air pollution (HAP) exposure or cookstove intervention to reduce HAP and cord blood mononuclear cell (CBMC) mitochondrial deoxyribonucleic acid copy number (mtDNAcn), an oxidative stress biomarker, are unknown.Pregnant women were recruited and randomized to one of two cookstove interventions, including a clean-burning liquefied petroleum gas (LPG) stove, or control. Prenatal HAP exposure was determined by serial, personal carbon monoxide (CO) measurements. CBMC mtDNAcn was measured by quantitative polymerase chain reaction. Multivariable linear regression determined associations between prenatal CO and cookstove arm on mtDNAcn. Associations between mtDNAcn and birth outcomes and effect modification by infant sex were explored.LPG users had the lowest CO exposures ( = 0.02 by ANOVA). In boys only, average prenatal CO was inversely associated with mtDNAcn (β = -14.84, SE = 6.41, = 0.03, per 1ppm increase in CO). When examined by study arm, LPG cookstove had the opposite effect in all children (LPG β = 19.34, SE = 9.72, = 0.049), but especially boys (β = 30.65, SE = 14.46, = 0.04), as compared to Control. Increased mtDNAcn was associated with improved birth outcomes.Increased prenatal HAP exposure reduces CBMC mtDNAcn, suggesting cumulative prenatal oxidative stress injury. An LPG stove intervention may reverse this effect. Boys appear most susceptible.
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kaali2018prenatalinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kaali, Seyram;Jack, Darby;Delimini, Rupert;Hu, Lisa;Burkart, Katrin;Opoku-Mensah, Jones;Quinn, Ashlinn;Ae-Ngibise, Kenneth Ayuurebobi;Wylie, Blair;Boamah-Kaali, Ellen Abrafi;Chillrud, Steven;Owusu-Agyei, Seth;Kinney, Patrick L;Baccarelli, Andrea A;Asante, Kwaku Poku;Lee, Alison;
Journal International journal of environmental research and public health
Year 2018
DOI
E26
URL
Keywords Keywords not found

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