mitochondrial type ii nad(p)h dehydrogenases in fungal cell death

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ID: 224755
2015
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Abstract
During aerobic respiration, cells produce energy through oxidative phosphorylation, which includes a specialized group of multi-subunit complexes in the inner mitochondrial membrane known as the electron transport chain. However, this canonical pathway is branched into single polypeptide alternative routes in some fungi, plants, protists and bacteria. They confer metabolic plasticity, allowing cells to adapt to different environmental conditions and stresses. Type II NAD(P)H dehydrogenases (also called alternative NAD(P)H dehydrogenases) are non-proton pumping enzymes that bypass complex I. Recent evidence points to the involvement of fungal alternative NAD(P)H dehydrogenases in the process of programmed cell death, in addition to their action as overflow systems upon oxidative stress. Consistent with this, alternative NAD(P)H dehydrogenases are phylogenetically related to cell death - promoting proteins of the apoptosis-inducing factor (AIF)-family.
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gonalves2015microbialmitochondrial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;A. Pedro Gonçalves;Arnaldo Videira
Journal povolžskaâ arheologiâ
Year 2015
DOI
10.15698/mic2015.03.192
URL
http://microbialcell.com/researcharticles/mitochondrial-type-ii-nadph-dehydrogenases-in-fungal-cell-death/
Keywords
programmed cell death fungi

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