diagnosed tuberculous meningitis using cerebrospinal fluid polymerase chain reaction in patients hospitalized with the diagnosis of meningitis in referral hospitals in isfahan

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2015
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Abstract
Background: Tuberculosis (TB) remains one of the leading infectious diseases throughout the world. Among various forms of extrapulmonary TB, tuberculous meningitis (TBM) is the most severe form and remains a major global health problem with a high mortality rate. Our study was designed to evaluate tuberculous polymerase chain reaction (PCR) positive rate in patients who present with fairly long symptoms of meningitis. Materials and Methods: The 162 Patients with an indolent onset of symptoms compatible with central nervous system infection were admitted. Sample of cerebrospinal fluid (CSF) was evaluated for biochemistry and tuberculous real-time PCR. Data analyzed by Student′s t-test and Fisher′s test. Results: Patients were mostly male (69.8%), with a median age of 43.69 ± 22.67 years. CSF real-time PCR results in 6 patients (3.7%) were positive for tuberculous DNA. Of these 6 patients, 4 of whom were men and two of whom were women. In other words, the frequency of positive tuberculous DNA was in male 5.3% and female 1.4%, respectively. Conclusion: Given that we live in Iran and in the vicinity of the tuberculous endemic countries, if we face a meningitis case with lasting symptoms and tendency to be chronic, TBM should be considered.
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shirani2015journaldiagnosed Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kiana Shirani;Zahra Talaei;Majid Yaran;Behrooz Ataei;Ali Mehrabi-Koushki;Farzin Khorvash
Journal 2017 ieee international conference on communication, networks and satellite, comnetsat 2017 - proceedings
Year 2015
DOI
DOI not found
URL
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=3;spage=224;epage=227;aulast=Shirani
Keywords
meningitis real-time polymerase chain reaction

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