oogram studies in mice infected with schistosoma mansoni and treated with dexamethasone oograma em camundongos infectados com schistosoma mansoni e tratados com dexametasona

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ID: 224213
1994
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Abstract
Mice infected with about 90 cercariae of Schistosoma mansoni (LE strain) were treated during five consecutive days with dexamethasone (50 mg/Kg, subcutaneously), starting on the 42th day of infection. Groups of five mice were then daily sacrificed from the first day after onset of treatment until the first day after. The perfusion of the portal system was performed and a piece of the intestine was processed for qualitative and quantitative oograms. This treatment carries to larger numbers of eggs in the tissues of treated mice, when compared with untreated groups. No changes were observed in the kinetics of oviposition, as all stages of viable eggs were observed in the tissues of treated and control mice. These data reinforce the hypothesis of a partial blockade of the egg excretion in immunossupressed mice.
Camundongos infectados com cerca de 90 cercárias da cepa LE de Schistosoma mansoni foram tratados durante 5 dias consecutivos com dexametasona (50mg/ Kg, subcutaneamente) a partir do 42º dia de infecção. Grupos de cinco camundongos foram sacrificados diariamente após o primeiro dia do início do tratamento até o primeiro dia após o término. A perfusão do sistema porta foi feita e fragmentos do intestino foram processados para a realização de oogramas qualitativos e quantitativos. O tratamento leva a um maior número de ovos nos tecidos dos camundongos tratados, se comparado com os grupos não tratados. Nenhuma mudança foi observada na cinética de oviposição, e ovos viáveis em todos os estádios evolutivos foram observados nos tecidos de camundongos tratados e controles. Estes dados reforçam a hipótese de um bloqueio parcial na saída de ovos dos tecidos do intestino para o lúmem intestinal em camundongos imunossuprimidos.
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Authors ;Marco Victor Hermeto;Rosilene Siray Bicalho;Roney Elias da Silva;Alan Lane de Melo;Leógenes Horácio Pereira
Journal 2017 12th international conference for internet technology and secured transactions, icitst 2017
Year 1994
DOI
10.1590/S0036-46651994000200001
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651994000200001
Keywords
schistosomiasis schistosoma mansoni glucocorticoids dexamethasone tropical medicine oogramarctic medicine

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