impairment of hepcidin upregulation by lipopolysaccharide in the interleukin-6 knockout mouse brain
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2017
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Abstract
To find out whether the Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is involved in the expression of hepcidin in the mouse brain in vivo, we investigated the phosphorylation of STAT3, as well as the expression of hepcidin mRNA, ferroportin 1 (Fpn1) and ferritin light chain (Ft-L) proteins in the cortex and hippocampus of LPS-treated wild type (IL-6+/+) and IL-6 knockout (IL-6-/-) mice. We demonstrated that IL-6 knockout could significantly reduce the response of hepcidin mRNA, phospho-STAT3, Fpn1 and Ft-L protein expression to LPS treatment, in both the cortex and hippocampus of mice. Also, Stattic, an inhibitor of STAT3, significantly reduced the expression of phospho-STAT3 and hepcidin mRNA in the cortex and hippocampus of the LPS-treated wild type mice. These findings provide in vivo evidence for the involvement of the IL-6/STAT3 signaling pathway in the expression of hepcidin.
| Reference Key |
zhang2017frontiersimpairment
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| Authors | ;Fa-Li Zhang;Fa-Li Zhang;Hui-Min Hou;Zhi-Nan Yin;Lan Chang;Fe-Mi Li;Y.-J. Chen;Ya Ke;Zhong-Ming Qian |
| Journal | international journal of nanomedicine |
| Year | 2017 |
| DOI |
10.3389/fnmol.2017.00367
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