agaricoglycerides protect against hepatic ischemia/reperfusion injury by attenuating inflammatory response, oxidative stress, and expression of nf-κb
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2015
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Abstract
We have investigated the effects of agaricoglycerides (AG) in a mouse model of hepatic I/R injury. I/R triggered increases/changes in markers of liver injury, hepatic oxidative stress, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nuclear factor κB (NF-κB). AG significantly reduced the extent of liver inflammation and oxidative stress and also attenuated the NF-κB activation as well as TNF-α and IL-1β production. Our results indicate that AG may represent a novel protective strategy against I/R-induced injury and inflammatory diseases.
| Reference Key |
zhao2015evidence-basedagaricoglycerides
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|---|---|
| Authors | ;Xiang-qian Zhao;Bin Liang;Yang Liu;Xiao-qiang Huang |
| Journal | ACS applied materials & interfaces |
| Year | 2015 |
| DOI |
10.1155/2015/142736
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| URL | |
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