a chinese herbal decoction, danggui buxue tang, stimulates proliferation, differentiation and gene expression of cultured osteosarcoma cells: genomic approach to reveal specific gene activation

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ID: 223612
2011
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Abstract
Danggui Buxue Tang (DBT), a Chinese herbal decoction used to treat ailments in women, contains Radix Astragali (Huangqi; RA) and Radix Angelicae Sinensis (Danggui; RAS). When DBT was applied onto cultured MG-63 cells, an increase of cell proliferation and differentiation of MG-63 cell were revealed: both of these effects were significantly higher in DBT than RA or RAS extract. To search for the biological markers that are specifically regulated by DBT, DNA microarray was used to reveal the gene expression profiling of DBT in MG-63 cells as compared to that of RA- or RAS-treated cells. Amongst 883 DBT-regulated genes, 403 of them are specifically regulated by DBT treatment, including CCL-2, CCL-7, CCL-8, and galectin-9. The signaling cascade of this DBT-regulated gene expression was also elucidated in cultured MG-63 cells. The current results reveal the potential usage of this herbal decoction in treating osteoporosis and suggest the uniqueness of Chinese herbal decoction that requires a well-defined formulation. The DBT-regulated genes in the culture could serve as biological responsive markers for quality assurance of the herbal preparation.
Reference Key
choi2011evidence-baseda Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Roy C. Y. Choi;Qiu T. Gao;Anna W. H. Cheung;Judy T. T. Zhu;Faye T. C. Lau;Jun Li;Winnie Z. M. Li;Glanice K. Y. Chu;Ran Duan;Jerry K. H. Cheung;An W. Ding;Kui J. Zhao;Tina T. X. Dong;Karl W. K. Tsim
Journal ACS applied materials & interfaces
Year 2011
DOI
10.1093/ecam/nen085
URL
http://dx.doi.org/10.1093/ecam/nen085
Keywords
Other systems of medicine

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