regulation and function of rfrp-3 (gnih) neurons during postnatal development
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ID: 223594
2015
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Abstract
RFamide-related peptide-3 (RFRP-3; mammalian ortholog to GnIH) potently inhibits gonadotropin secretion in mammals. Studies of RFRP-3 immunoreactivity and Rfrp expression (the gene encoding RFRP-3) in mammalian brains have uncovered several possible pathways regulating RFRP-3 neurons, shedding light on their potential role in reproduction and other processes, and pharmacological studies have probed the target sites of RFRP-3 action. Despite this, there is currently no major consensus on RFRP-3’s specific endogenous role(s) in reproductive physiology. Here we discuss the latest evidence relating to RFRP-3 neuron regulation and function during development and sexual maturation, focusing on rodents. We highlight significant changes in RFRP-3 and Rfrp expression, as well as RFRP-3 neuronal activation, during key stages of postnatal and pubertal development and also discuss recent evidence testing the requisite role of RFRP-3 receptors for normal pubertal timing and developmental LH secretion. Interestingly, some findings suggest that endogenous RFRP-3 signaling may not be necessary for the puberty timing, at least in some species, forcing new hypotheses to be generated regarding this peptide’s functional significance to sexual maturation and development.
| Reference Key |
poling2015frontiersregulation
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| Authors | ;Matthew C Poling;Alexander S. Kauffman |
| Journal | aip advances |
| Year | 2015 |
| DOI |
10.3389/fendo.2015.00150
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