análisis ecocardiográfico de la geometría ventricular izquierda en ratas espontáneamente hipertensas echocardiographic study of left ventricular geometry the in spontaneously hypertensive rats
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SteadyRanked #6 of 101 articles by views in proceedings on: 2016 ieee central america and panama student conference, conescapan 2016
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Abstract
The purpose of this study was to analyze by echocardiogram left ventricular (LV) geometry in spontaneously hypertensive rats (SHR). Echocardiographic study, systolic blood pressure and heart rate were obtained in 114 male, 4-month old rats, 73 SHR and 41 Wistar (W). Left ventricular mass index (LVMI), relative wall thickness (RWT), stroke volume, and mid ventricular shortening were calculated with echocardiographic parameters. Normal LV was defined considering the mean plus 2 SD of LVMI and RWT in W. Patterns of abnormal LV geometry were: LV concentric remodeling, LVMI < 2.06 mg/g - RWT > 0.71; eccentric, left ventricular hypertrophy (LVH), LVMI > 2.06 mg/g - RWT < 0.71; and concentric LVH, LVMI > 2.06 mg/g - RWT > 0.71. Systolic blood pressure (SBP) and cardiac output (CO) were used to obtain total peripheral resistance (TPR). twelve % of SHR had normal LV geometry; 18% LV concentric remodeling; 33% concentric LVH and 37% eccentric LVH. LV concentric remodeling showed the smallest CO and highest TPR of any group. Eccentric LVH presented similar SBP as the other SHR groups and high CO with lower TPR. Our findings in SHR exhibit different patterns of LV geometry like in humans. These results strengthen the similarities between SHR and human essential hypertension.
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escudero2009medicinaanlisis
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| Authors | ;Eduardo M. Escudero;Oscar A. Pinilla;Verónica B. Carranza |
| Journal | proceedings on: 2016 ieee central america and panama student conference, conescapan 2016 |
| Year | 2009 |
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