moving from organ dose to microdosimetry: contribution of the monte carlo simulations

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ID: 222520
2005
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Abstract
When living cells are irradiated by charged particles, a wide variety of interactions occurs that leads to a deep modification of the biological material. To understand the fine structure of the microscopic distribution of the energy deposits, Monte Carlo event-by-event simulations are particularly suitable. However, the development of these track structure codes needs accurate interaction cross sections for all the electronic processes: ionization, excitation, Positronium formation (for incident positrons) and even elastic scattering. Under these conditions, we have recently developed a Monte Carlo code for electrons and positrons in water, this latter being commonly used to simulate the biological medium. All the processes are studied in detail via theoretical differential and total cross sections calculated by using partial wave methods. Comparisons with existing theoretical and experimental data show very good agreements. Moreover, this kind of detailed description allows one access to a useful microdosimetry, which can be coupled to a geometrical modelling of the target organ and then provide a detailed dose calculation at the nanometric scale.
Quando células vivas são irradiadas por partículas carregadas, ocorre uma grande variedade de interações, o que leva a uma modificação profunda do material biológico. Para entender a delicada estrutura da distribuição microscópica dos depósitos de energia, as simulações de Monte Carlo são particularmente adequadas. Entretanto, o desenvolvimento destes códigos necessitam de amostras representativa de interações perfeitas para todos os processos eletrônicos: ionização, excitação, formação de positrônico (para pósitrons incidentes) e mesmo espalhamento elástico. Nessas condições, nós desenvolvemos recentemente um código Monte Carlo para elétrons e pósitrons em água usada posteriormente para simular o meio biológico. Todos os processos são estudados detalhadamente via seções de choque calculada usando métodos de ondas parciais. Comparações com dados experimentais e teóricos mostram boa concordância. Além disto, esta descrição detalhada nos permite acessar esta útil microdosimetria, a qual pode ser acoplada a modelo geométrico de órgãos alvo e então fornece um cálculo detalhado da dose em escala nanométrica.
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champion2005brazilianmoving Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Christophe Champion
Journal current drug delivery
Year 2005
DOI
10.1590/S1516-89132005000700029
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700029
Keywords
monte carlo simulation electron microdosimetrybiotechnology

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