transformação anaplásica em carcinoma papilífero de tireóide
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ID: 222466
2002
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Abstract
OBJETIVO: Escrever a transformação de um Carcinoma Papilífero de Tireóide em Carcinoma Anaplásico. MÉTODOS: relato de caso de uma paciente portadora de Carcinoma Papilífero de glândula tireóide e tratada no Serviço de Cirurgia de Cabeça e Pescoço do HCMRPUSP. Espécimes histológicos foram colhidas durante o decorrer do tratamento e estudos anatomopatológico e imuno-histoquímico foram realizados para direcionar conduta médica. RESULTADOS: A análise anatomopatológica e imuno-histoquímica realizada mostrou mudança de padrão de diferenciação celular durante a evolução da doença em questão. Tais dados, correlatados às características clínico-radiológicas tornam o caso compatível com a transformação anaplásica tireoideana a partir de um tumor bem diferenciado-Carcinoma Papilífero de tireóide. CONCLUSÕES: Observa-se nítida diferença das características evolutivas dos dois tipos de tumores malignos presentes nesta paciente: a primeira com comportamento "benigno" e indolente e a segunda agressiva, e fatal, sugerindo transformação anaplásica - como já descrita previamente na literatura.
Anaplastic transformation of a differentiated (papillary or folicular) tyroid carcinoma is a very rare event. Ocasionally, indiffentiated and well differentiated carcinomas occur simultaneously at the same metastatic focci. All well-differentiated tyroid carcinomas could have this evolution. Some authors suggest that this transformation is induced by radioactive iodine, external radiotherapy or long term goiter. The purpose of this article is to show an anaplastic transformation in a 69 year old woman with papillary thyroid carcinoma operated by Head and Neck Surgery team at Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP.
Anaplastic transformation of a differentiated (papillary or folicular) tyroid carcinoma is a very rare event. Ocasionally, indiffentiated and well differentiated carcinomas occur simultaneously at the same metastatic focci. All well-differentiated tyroid carcinomas could have this evolution. Some authors suggest that this transformation is induced by radioactive iodine, external radiotherapy or long term goiter. The purpose of this article is to show an anaplastic transformation in a 69 year old woman with papillary thyroid carcinoma operated by Head and Neck Surgery team at Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP.
| Reference Key |
tiveron2002actatransformao
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| Authors | ;Rogerio Costa Tiveron;Rui Celso Martins Mamede;Francisco Verissimo De Mello-Filho;Hilton Marcos Alves Ricz;Daniel Hardy Melo;Gilberto Maggioni Junior;Leonardo Souza Kruschewsky;Ernandes Kaoru Nakamura |
| Journal | forensic science international |
| Year | 2002 |
| DOI |
10.1590/S0102-86502002000900025
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| URL | |
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