antioxidant stress and anti-inflammation of pparα on warm hepatic ischemia-reperfusion injury

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ID: 222351
2012
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Ranked #30 of 58 articles by views in Life (Basel, Switzerland)

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Abstract
Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating the lipid and lipoprotein metabolism, PPARα also undertakes the task of organ protection. In this paper, related literature has been summarized and we come to the conclusion that administration of PPARα agonists can strengthen the antioxidant and anti-inflammation defense system by the upregulation of the expression of antioxidant enzymes and inhibition of NF-κB activity. This may provide a potential clinical treatment for hepatic ischemia-reperfusion injury.
Reference Key
gao2012pparantioxidant Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Zhixin Gao;Yuan-Hai Li
Journal Life (Basel, Switzerland)
Year 2012
DOI
10.1155/2012/738785
URL
http://dx.doi.org/10.1155/2012/738785
Keywords
Biology (General)

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