tumor-stromal interactions influence radiation sensitivity in epithelial- versus mesenchymal-like prostate cancer cells

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ID: 222012
2010
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Abstract
HS-27a human bone stromal cells, in 2D or 3D coultures, induced cellular plasticity in human prostate cancer ARCaPE and ARCaPM cells in an EMT model. Cocultured ARCaPE or ARCaPM cells with HS-27a, developed increased colony forming capacity and growth advantage, with ARCaPE exhibiting the most significant increases in presence of bone or prostate stroma cells. Prostate (Pt-N or Pt-C) or bone (HS-27a) stromal cells induced significant resistance to radiation treatment in ARCaPE cells compared to ARCaPM cells. However pretreatment with anti-E-cadherin antibody (SHEP8-7) or anti-alpha v integrin blocking antibody (CNT095) significantly decreased stromal cell-induced radiation resistance in both ARCaPE- and ARCaPM-cocultured cells. Taken together the data suggest that mesenchymal-like cancer cells reverting to epithelial-like cells in the bone microenvironment through interaction with bone marrow stromal cells and reexpress E-cadherin. These cell adhesion molecules such as E-cadherin and integrin alpha v in cancer cells induce cell survival signals and mediate resistance to cancer treatments such as radiation.
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josson2010journaltumor-stromal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sajni Josson;Starlette Sharp;Shian-Ying Sung;Peter A. S. Johnstone;Ritu Aneja;Ruoxiang Wang;Murali Gururajan;Timothy Turner;Leland W. K. Chung;Clayton Yates
Journal joule
Year 2010
DOI
10.1155/2010/232831
URL
http://dx.doi.org/10.1155/2010/232831
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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