dual-modality imaging probes with high magnetic relaxivity and near-infrared fluorescence based highly aminated mesoporous silica nanoparticles
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2016
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Abstract
Dual-modal imaging by combining magnetic resonance (MR) and near-infrared (NIR) fluorescence can integrate the advantages of high-resolution anatomical imaging with high sensitivity in vivo fluorescent imaging, which is expected to play a significant role in biomedical researches. Here we report a dual-modality imaging probe (NIR/MR-MSNs) fabricated by conjugating NIR fluorescent heptamethine dyes (IR-808) and MR contrast agents (Gd-DTPA) within highly aminated mesoporous silica nanoparticles (MSNs-NH2). The dual-modality imaging probes NIR/MR-MSNs possess a size of ca. 120 nm. The NIR/MR-MSNs show not only near-infrared fluorescence imaging property with an emission peak at 794 nm, but also highly MR T1 relaxivity of 14.54 mM−1 s−1, which is three times more than Gd-DTPA. In vitro experiment reveals high uptake and retention abilities of the nanoprobes, while cell viability assay demonstrates excellent cytocompatibility of the dual-modality imaging probe. After intratumor injection with the NIR/MR-MSNs, MR imaging shows clear anatomical border of the enhanced tumor region while NIR fluorescence exhibits high sensitive tumor detection ability. These intriguing features suggest that this newly developed dual-modality imaging probes have great potential in biomedical imaging.
| Reference Key |
fei-peng2016journaldual-modality
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| Authors | ;Zhu Fei-Peng;Chen Guo-Tao;Wang Shou-Ju;Liu Ying;Tang Yu-Xia;Tian Ying;Wang Jian-Dong;Wang Chun-Yan;Wang Xin;Sun Jing;Teng Zhao-Gang;Lu Guang-Ming |
| Journal | reproductive biology and endocrinology |
| Year | 2016 |
| DOI |
10.1155/2016/6502127
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