inhibitor y effect on key enzymes relevant to acute type-2 diabetes and antioxidative activity of ethanolic extract of artocarpus heterophyllus stem bark
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2016
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Abstract
Objective: To investigate the in vitro antioxidant activity of ethanolic extract of Artocarpus heterophyllus (A. heterophyllus) stem bark and its inhibitory effect on a-amylase
and a-glucosidase.
Methods: The A. heterophyllus stem bark was extracted using methanol and tested for
antioxidative activity.
Results: The results revealed that the ethanolic extract has polyphenolics and free radical
scavenging compounds which were significantly higher (P < 0.05) than their respective
standard, at concentration dependent manner. The ethanolic extract of A. heterophyllus stem
bark was observed to show inhibitory activities on a-amylase and a-glucosidase with IC50 of
(4.18 ± 0.01) and (3.53 ± 0.03) mg/mL, respectively. The Lineweaver-Burk plot revealed
that ethanolic extract of A. heterophyllus stem bark exhibited non-competitive inhibition for
a-amylase and uncompetitive inhibition for a-glucosidase activities. Also, gas chromatography–mass spectrometry showed the presence of different bioactive compounds in extract.
Conclusions: Therefore, it can be inferred from this study that ethanolic extract of
A. heterophyllus stem bark may be useful in the management of diabetes mellitus
probably due to bioactive compounds observed in the extract.
| Reference Key |
ajiboye2016journalinhibitor
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|---|---|
| Authors | ;Basiru Olaitan Ajiboye;Oluwafemi Adeleke Ojo;Oluwatosin Adeyonu;Oluwatosin Imiere;Isreal Olayide;Adewale Fadaka;Babatunji Emmanuel Oyinloye |
| Journal | journal of education, health and sport |
| Year | 2016 |
| DOI |
10.1016/j.joad.2016.08.011
|
| URL | |
| Keywords |
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