detection of anti-ige anti-fcεri α chain auto-antibodies in patients with atopic dermatitis
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2000
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Abstract
Anti-IgE and anti-FcεRI α chain auto-antibodies have been detected in the sera of atopic and non-atopic subjects; however, the biological activity of these auto-antibodies is still unclear. These two kinds of autoantibodies were examined in atopic dermatitis (AD) patients. In results, 12 of 92 AD patients have the anti-IgE, eight have the anti-FcεRI α auto-antibodies and two have both auto-antibodies. Furthermore, biological characterization of these auto-antibodies has been performed. In results, three of 12 samples with the anti-IgE auto-antibodies exhibited inhibitory activity for IgE-FcεRI α binding. Two of the eight samples with the anti-FcεRI α auto-antibodies and one of the two samples with both auto-antibodies had histamine releasing activity. It is documented here that both anti-IgE and anti-FcεRI α auto-antibodies were detected in some AD patients, some anti-IgE auto-antibodies had inhibitory activity for IgE-FcεRI binding and also histamine releasing activity was detected in the anti-FcεRI α chain auto-antibody.
| Reference Key |
hayashi2000allergologydetection
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| Authors | ;Satoru Hayashi;Hajime Suto;Naruhito Wada;Hideoki Ogawa;Ko Okumura;Chisei Ra |
| Journal | current drug discovery technologies |
| Year | 2000 |
| DOI |
10.1046/j.1440-1592.2000.00158.x
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