subtle cardiovascular dysfunction in the unilateral 6-hydroxydopamine-lesioned rat
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ID: 221374
2010
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Abstract
The present study evaluated whether the unilateral 6-hydroxydopamine (6-OHDA) model of Parkinson's disease produces autonomic deficits. Autonomic parameters were assessed by implanting a small radiofrequency telemetry device which measured heart rate variability (HRV), diurnal rhythms of heart rate (HR), core body temperature (cBT) and locomotor activity (LA). Rats then received 6-OHDA lesion or sham surgery. 6-OHDA lesioned rats exhibited head and body axis biases, defective sensorimotor function (“disengage” test), and prominent apomorphine rotation (all P<.05 versus controls). Diurnal rhythm of HR was lower for 6-OHDA lesioned rats (n=8) versus controls (n=6; P<.05). Whilst HR decreased similarly in both groups during the day, there was a greater decrease in HR for the 6-OHDA lesioned rats at night (by 38 b.p.m. relative to 17 b.p.m. for controls). LA and cBT did not differ between surgery groups. This study indicates the unilateral 6-OHDA model of PD shows subtle signs of cardiovascular autonomic dysfunction.
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| Reference Key |
slack2010parkinson'ssubtle
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|---|---|
| Authors | ;K. Slack;R. Billing;S. Matthews;H. N. Allbutt;R. Einstein;J. M. Henderson |
| Journal | heat and mass transfer/waerme- und stoffuebertragung |
| Year | 2010 |
| DOI |
10.4061/2010/427810
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| URL | |
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