n-acetyl-l-cysteine protects the enterocyte against oxidative damage by modulation of mitochondrial function
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2016
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Abstract
The neonatal small intestine is susceptible to damage caused by oxidative stress. This study aimed to evaluate the protective role of antioxidant N-acetylcysteine (NAC) in intestinal epithelial cells against oxidative damage induced by H2O2. IPEC-J2 cells were cultured in DMEM-H with NAC and H2O2. After 2-day incubation, IPEC-J2 cells were collected for analysis of DNA synthesis, antioxidation capacity, mitochondrial respiration, and cell apoptosis. The results showed that H2O2 significantly decreased (P<0.05) proliferation rate, mitochondrial respiration, and antioxidation capacity and increased cell apoptosis and the abundance of associated proteins, including cytochrome C, Bcl-XL, cleaved caspase-3, and total caspase-3. NAC supplementation remarkably increased (P<0.05) proliferation rate, antioxidation capacity, and mitochondrial bioenergetics but decreased cell apoptosis. These findings indicate that NAC might rescue the intestinal injury induced by H2O2.
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| Reference Key |
xiao2016mediatorsn-acetyl-l-cysteine
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|---|---|
| Authors | ;Hao Xiao;Miaomiao Wu;Fangyuan Shao;Guiping Guan;Bo Huang;Bie Tan;Yulong Yin |
| Journal | polyhedron |
| Year | 2016 |
| DOI |
10.1155/2016/8364279
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| URL | |
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