breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction

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ID: 221005
2016
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Abstract
Objective(s):Our recent report indicates that breviscapine play a protective role of the kidney by down-regulating transforming growth factor-β1(TGF-β1), α-smooth muscle actin (α-SMA) and alleviating interstitial fibrosis following unilateral ureteral obstruction (UUO). In this study, we investigate the effect of breviscapine on changes of renal water and sodium transport proteins in response to UUO. Materials and Methods: Male Sprague-Dawley rats were divided into 3 groups, sham group, UUO group and UUO treat with breviscapine. After 4, 7 and 14 days, histologic changes and interstitial collagen were determined microscopically following hematoxylin and eosin (H&E) and Masson's trichrome staining. The expression of Aquaporins (AQP-2) and γ-epithelial sodium channel (γ-ENaC) were investigated using immunohistochemistry and Western blot in each group. Results:Breviscapine treatment decrease the tubular injury index and the degree of interstitial collagen deposition significantly compared with the UUO group (P
Reference Key
mei2016iranianbreviscapine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yang Mei;Zhuang Yangyang;Luo Shuai;Jin Hao;Yang Yirong;Cai Yong;Xia Peng;Chen Bicheng;Zhang Yan
Journal PloS one
Year 2016
DOI
DOI not found
URL
http://ijbms.mums.ac.ir/article_6943_2f21c7cc6919793983d8d7190c6cdb99.pdf
Keywords
antioxidant HPLC biological properties rsm

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